Launched in ’06 as part of the E-Class lineup, the E350 is a premium sedan from German automakers Mercedes.
It offers a luxurious ride, a lavish cabin, innovative technology and a powerful engine.
If you’re considering purchasing an E350 as your next vehicle you might be wondering about its average lifespan.
We’ll cover that in this article, read on to find out…
Table of Contents
Here is the short answer to how long Mercedes-Benz E350 last:
The Mercedes-Benz E350 is a reliable, luxury midsize sedan that can last between 200,000 – 250,000 miles on average when properly maintained and driven conservatively. Based on an annual mileage of 15,000 miles, it can last 13 to 17 years before breaking down or requiring uneconomical repairs.
How Many Miles Can You Expect from a Mercedes-Benz E350?
Despite getting off to a bumpy start in 2006 (lots of problems with this model) the E350 has gone on to prove that it can withstand the test of time.
You can still find many early year models on the road today which is a testament to the durability of this car.
During our investigations we found no shortage of satisfied E350 owners who have well over 150,000 miles on their original drivetrains – we even encountered a handful of owners who had close to 250,000 miles.
Based on industry data we believe a reasonable lifespan for the E350 falls in the region of 200,000 – 250,000 miles. Once this type of mileage has been achieved there is a much greater chance of big-ticket items failing such as the engine or transmission – when this happens the cost of repairs may outweigh the value of the vehicle.
That’s not to say these mileages can’t be surpassed or that the car won’t fall short of these milestones as individual results will be heavily impacted by usage, personal care, and to some extent, luck.
How you drive your Mercedes will also play a big part in how long it continues to drive.
Sure, they’re typically designed to be driven sportingly, but overworking the engine or being too aggressive with the brake and gas pedals can be hard on any vehicle.
To keep your E350 running smoothly for many years to come, we recommend:
- Keeping up to date with the manufacturer’s maintenance schedule
- Carrying out basic routine checks such as tire pressures and fluid levels.
- Adopting smooth driving habits to reduce wear and tear on components
Every new Mercedes E350 comes with a 4-year/50,000-mile basic warranty and a 4-year/50,000-mile powertrain warranty.
Do Mercedes-Benz E350 Rust Easily?
Modern day Mercedes-Benz vehicles are generally very rust-resistant and the E350 is no exception. This is thanks to anti-corrosion coatings and the under-body of the car being galvanized and sealed.
Mercedes did have a significant rust problem from the late 90s to early 2000s when they switched to water-based paints, however between 2002 and 2004, they introduced galvanized panels which helped resolve the issue.
During our research we struggled to find many rust complaints about the E350, the few we did uncover were mostly related to older E-Class vehicles.
Rust is much more of an issue in humid climates, places where roads are aggressively salted during the winter and coastal regions due to salt in the air.
If you live in a higher-risk area, we recommend taking extra precautions, however additional rust-proofing on a new Mercedes is generally not advised due to the high standard of rust-proofing that takes place during the manufacturing process.
Tips to keep your E350 rust-free:
- Regularly wash and dry your car: This includes its underside (especially during the winter) to remove the salt, dirt and grime that causes rust. We recommend having a detail shop wash everything underneath at the end of each winter.
- Repair paint damage and scratches: Exposed metal will oxidize. If it’s beyond a DIY fix, speak to your local body repair shop.
- Garage: Store your E350 in a garage to protect it from harsh weather and bird droppings.
- Waxing: Wax your car twice a year. Not only will this make your E350 look amazing, but it also gives a protective coating against rust.
- Ceramic Coating: A popular choice for those who want to add an extra layer of protection to the paint job.
Any signs of rusting on a new Mercedes is out of the ordinary and should be covered under warranty.
What is High Mileage for a Mercedes-Benz E350?
A Mercedes-Benz E350 with 100,000 miles is considered high mileage, and a riskier investment – although there are many factors to consider, primarily the vehicle’s maintenance history, its overall condition and number of previous owners.
Buying one with over 100,000 miles isn’t necessarily a bad decision.
A well-maintained E350 with 100,000 miles might be a better purchase than one with 70,000 miles that had lots of owners and led a rough life or was previously a rental car.
Keep in mind that maintenance costs on a used Mercedes-Benz can be much higher than that of a non-luxury brand and if you are buying from a private seller you will not get any warranty.
When buying a second-hand E350, consider the following:
- Maintenance history. Check that the car was properly serviced and the owner can provide evidence of this.
- Get a second opinion. Take it to an independent auto diagnostic clinic or have it inspected by a mechanic.
- Check the CarFax. This guarantees nothing, but it will provide a clearer picture of wear and tear. Ensure it has minimal damage, if any. Review the information to make sure if something happened, such as engine- or transmission-related.
- The number of previous owners. As a general rule, less is better. More owners usually mean more wear-and-tear. If one family owned it and drove the full mileage and serviced the car, then you can almost guarantee they took good care of it throughout their ownership.
- How long you are planning on keeping the car. If you’re planning on keeping the car for a long time, you should evaluate whether the short-term savings outweigh spending a bit extra on something more reliable.
If the car has averaged a lot more or less than 10,000 to 15,000 miles per year, you might want to further investigate why – for example – a 4-year-old model that has 100,000 miles.
How Long Do Mercedes-Benz E350 Last Compare to Similar Car Models?
In this section, we’ll compare the E350 to some of its rivals.
Mercedes-Benz E350 vs Audi A6
Comfortable, spacious, handsome – the Audi A6 is now in its fifth generation and still going strong.
The Audi A6 can last approximately 200,000 or 13 years, slightly less than is expected of the E350.
- According to RepairPal, the A6 scores an average reliability rating of 3.5 out of 5.0, which ranks it 8th out of 30 for luxury full-size cars.
- The E350 scores an average reliability rating from RepairPal of 3.5 out of 5.0, which ranks it 12th out of 30 luxury full-size vehicles.
- Across all model years, Consumer Reports has given the A6 an average of 3.0 out of 5.0 for reliability vs. 3 out of 5.0 for Mercedes E-Class.
- The A6 has an annual average repair and maintenance cost of $987 vs. $788 for the E350.
- J.D. Power rated the A6 with a consumer reliability rating of 68 out of 100, while the E350 scored a rating of 75 out of 100.
- The Kelley Blue Book consumer reliability ratings score the A6 a 4.3 out of 5.0 versus 4.4 out of 5.0 for the E350.
The styling of the A6 is more minimal in comparison to the E350 and its interior lacks the visual appeal of its German rival.
However, these cars are closely matched across the board and we’d advise taking both for a test drive before making any big decisions.
Mercedes-Benz E350 vs. BMW 5 Series
BMW launched the 5 Series range in 1972 and this German executive sedan is now in its 7th illustrious generation.
The BMW 5 series can last on average between 200,000 to 250,000 miles or about 13 to 17 years equal to that of the E350.
- According to RepairPal, the 5 Series scored a below-average reliability rating of 3.0 out of 5.0, which ranks it 13th out of 30 in luxury full-size cars.
- The E350 scores an average reliability rating from RepairPal of 3.5 out of 5.0, which ranks it 12th out of 30 luxury full-size cars.
- Across all model years, Consumer Reports has given the 5 Series an average of 2.5 out of 5.0 for reliability vs. 3 out of 5.0 for Mercedes E-Class.
- The 5 Series has an annual average repair and maintenance cost of $968 vs. $788 for E350.
- J.D. Power rated the 5 Series with a consumer reliability rating of 77 out of 100, while the E350 scored 75 out of 100.
- The Kelley Blue Book consumer reliability ratings score the 5 Series a 4.7 out of 5.0 versus 4.4 out of 5.0 for the E350.
It’s a very tough choice between these two and the final decision will likely come down to which badge you prefer most.
You can’t go far wrong with either of these – both cars offer great performance, luxury and state-of-the-art tech.
Mercedes-Benz E350 vs. Lexus ES 350
Featuring a sleek, coupe-like silhouette the Japanese-made ES 350 combines comfort, efficiency and luxury.
The Lexus ES 350 can last between 250,000 to 300,000 miles or about 17 to 20 years, which is slightly more than the E350.
- According to RepairPal, the Lexus model scores a above-average reliability rating of 4.0 out of 5.0, which ranks it 4th out of 31 in luxury mid-size cars.
- The Lexus E350 scores an average reliability rating from RepairPal of 3.5 out of 5.0, which ranks it 12th out of 30 luxury full-size cars.
- Across all model years, Consumer Reports has given the Lexus model an average of 4.5 out of 5 for reliability vs. 2.5 out of 5 for the E350.
- The Lexus ES350 has an annual average repair and maintenance cost of $468 vs. $788 for for Mercedes E-Class.
- J.D. Power rated the Lexus with a consumer reliability rating of 79 out of 100, while the E350 scored 75 out of 100.
- The Kelley Blue Book consumer reliability ratings score the Lexus ES350 a 4.4 out of 5.0 versus 4.4 out of 5.0 for the E350.
The Lexus might not have the brand prestige of the Mercedes-Benz however its reliability is world-class.
Is the Mercedes-Benz E350 Reliable?
From our study of the E350, we can conclude that earlier models of this Mercedes range were less dependable than newer models. Recent models have received stronger reliability scores from consumers and auto-review websites.
Mercedes isn’t considered one of the more reliable manufacturers and German vehicles in general receive lower reliability ratings than their Japanese counterparts however the E350s reliability ratings are above average.
- RepairPal ranks the E350 as the 12th most reliable full-size car in its segment, with a reliability score of 3.5 out of 5.0.
- The Kelley Blue Book consumer rating index scores the E350 a reliability rating of 4.4 out of 5.0.
- J.D. Power rated the E350 with a consumer reliability score of 75 out of 100.
The E350 is packed with tech and gadgets and this means there are more things that can potentially go wrong
Reliability Compared to Luxury Fullsize Cars
|Acura RL||4.0 / 5.0|
|Lincoln Town Car||4.0 / 5.0|
|Lexus GS350||4.0 / 5.0|
|Volvo S80||4.0 / 5.0|
|Infiniti M37||3.5 / 5.0|
|Infiniti M35||3.5 / 5.0|
|Hyundai Genesis||3.5 / 5.0|
|Audi A6||3.5 / 5.0|
|Lexus LX570||3.5 / 5.0|
|Lexus LS460||3.5 / 5.0|
|Cadillac XTS||3.5 / 5.0|
|Mercedes-Benz E350||3.5 / 5.0|
|BMW 528i||3.5 / 5.0|
|Cadillac DTS||3.0 / 5.0|
|Mercedes-Benz CLS550||2.5 / 5.0|
|Mercedes-Benz E550||2.5 / 5.0|
|Audi A6 Quattro||2.5 / 5.0|
|BMW 535i||2.5 / 5.0|
|Jaguar XJ||2.5 / 5.0|
|BMW 528i xDrive||2.5 / 5.0|
|Hyundai Equus||2.0 / 5.0|
|Mercedes-Benz SL550||2.0 / 5.0|
|BMW 535i xDrive||2.0 / 5.0|
|BMW 650i||2.0 / 5.0|
|Mercedes-Benz S550||2.0 / 5.0|
|BMW 750Li||2.0 / 5.0|
|Audi A7 Quattro||2.0 / 5.0|
|Audi A8 Quattro||1.5 / 5.0|
|BMW 550i||1.5 / 5.0|
|Porsche Panamera||0.5 / 5.0|
|Avg. Lux. Fullsize Car||2.5|
The Best and Worst Years for Mercedes-Benz E350
As with all vehicles on our roads, the E350 has had its good and bad years…
Worst Model Year
According to Car Complaints, the 2006 Mercedes E350 was the worst model year, based on several factors such as repair cost and average mileage when problems occur. The 2006 E350 also received the most overall complaints on the Car Complaints and Car Problem Zoo websites.
The 2006 E350 was plagued by engine problems, fuel system problems and transmission problems – fortunately for Mercedes enthusiasts, newer models have improved significantly.
Worst problems for the E350:
- Balance shaft failure on 2006 models – occuring at an average of 85k miles costing an average of $4800 to fix
- Gas tanks leak when full on 2007 models – occuring at an average of 94k miles costing an average of $2400 to fix
- Paint bubbles under clear coat on 2012 models – occuring at an average of 24k miles costing an average of $7500 to fix
To be on the safe side we’d advise avoiding the model years 2006 and 2007 simply due to the high volume of problems.
Best Model Year
The best model years for the E350 are the most recent ones, in particular from 2020 onwards.
These have the lowest number of complaints and better reliability scores which shows Mercedes have gradually remedied issues inherent in earlier models.
Our standout choice would be the 2021 model thanks to its fresh exterior styling and the introduction of the latest MBUX infotainment software.
The latest E350 also scored an IIHS Top Safety Pick+ award for its overall performance in crash prevention and crashworthiness evaluations.
All 2021 E-Class vehicles come standard with a 12.3-inch touchscreen multimedia display which is controlled by voice activation and a touchpad.
Model Year and Number of Complaints
Here are the total number of complaints/problems about the E350 from the Car Complaints and Car Problem Zoo databases.
|Model Year||No. of Complaints|
|No. of Problems|
Car Problem Zoo
|2006 (Worst year)||42||376|
What About Recalls For These Models?
Detailed below are the number of recalls across all Mercedes-Benz E-Class vehicles.
A recall is issued when a manufacturer or the NHTSA (National Highway Traffic Safety Administration) deems that a vehicle or one or more of its components creates an unreasonable safety risk or does not meet minimum safety requirements – recall related problems are fixed free of charge.
To find out if your GLC has been subject to a recall you can check the Mercedes Benz website recall page, you’ll need your car’s 17-digit VIN.
- 2021: 10
- 2020: 9
- 2019: 14
- 2018: 16
- 2017: 20
- 2016: 9
- 2015: 10
- 2014: 9
- 2013: 7
- 2012: 7
- 2011: 9
- 2010: 5
- 2009: 2
- 2008: 4
- 2007: 5
- 2006: 4
Mercedes-Benz E350 Model Year List
- 2006 Mercedes-Benz E350
- 2007 Mercedes-Benz E350
- 2008 Mercedes-Benz E350
- 2009 Mercedes-Benz E350
- 2010 Mercedes-Benz E350
- 2011 Mercedes-Benz E350
- 2012 Mercedes-Benz E350
- 2013 Mercedes-Benz E350
- 2014 Mercedes-Benz E350
- 2015 Mercedes-Benz E350
- 2016 Mercedes-Benz E350
- 2017 Mercedes-Benz E350
- 2018 Mercedes-Benz E350
- 2019 Mercedes-Benz E350
- 2020 Mercedes-Benz E350
- 2021 Mercedes-Benz E350
Are Mercedes-Benz E350 Expensive to Maintain?
The maintenance cost on a Mercedes is usually higher than that of a non-luxury car brand, especially if you depend on the dealer to do all your repairs.
According to RepairPal, the average annual cost for repairs and maintenance on a Mercedes-Benz E350 is $788.
In comparison, the average luxury full-size vehicle is $976 while the average cost across all makes and models of vehicles in the United States is $652.
If you have an older, second-hand E350 you should find a local repair shop that specializes in Mercedes-Benz or german cars.
|Model||Avg. Annual |
|Probability of |
|Lincoln Town Car||$635||0.2||12%|
|Audi A6 Quattro||$1,056||1.1||12%|
|BMW 528i xDrive||$984||1.4||13%|
|BMW 535i xDrive||$1,123||1.4||16%|
|Audi A7 Quattro||$1,251||1.6||14%|
|Audi A8 Quattro||$1,298||1.1||20%|
|Avg. Lux. Fullsize Car||$976||0.8||14%|
How Long Do the Brakes Last?
Mercedes E350 brakes pads usually last between 30,000 – 70,000 miles depending on driving habits and driving conditions.
- You can expect your brakes to wear out sooner if you frequently stop and accelerate in rush-hour traffic.
- Brake pad replacement on a E350, which includes parts and labor, can cost anywhere between $150 – $300 per axle.
- Full and complete stops from a high speed are the #1 cause of premature brake pad wear.
- A sporty driving style will lead to faster deterioration of brakes, a slow and steady style will help them last longer.
How Long Do the Tires Last?
The stock tires on a Mercedes E350 usually last 50,000 miles or 3 years based on 15,000 miles of driving per year. However, they can wear out much sooner. This depends on various factors, such as driving habits, climate, and road conditions.
- Rotate tires every 5,000 miles to ensure even wear.
- If you have to drive on rough or flooded roads, or go off-roading, your tires will take more of a beating.
- Check your tire pressures every few weeks to make sure they’re at the correct tire pressure.
- Have a mechanic check your wheel alignment every 6 months
How Long Do Mercedes-Benz E350 Engines Last?
The Mercedes E350 engine will typically last 200,000 – 250,000 or 13 to 17 years. This can vary drastically depending on model year, maintenance and the overall care of the vehicle.
If you take good care of your Mercedes, there’s no reason these mileages can’t be exceeded.
You may also be interested in our article: How Long Do Mercedes C300 Last?
How Long Do Mercedes-Benz E350 Batteries Last?
The E350’s battery usually lasts between 3 – 5 years. A vehicle’s battery life varies depending on factors such as climate, driving habits, the type of battery, and more.
- Keep your battery tightly fastened: The vibrations of your car can loosen the connections, potentially resulting in short circuits and internal damage.
- Limit short rides: Quick car rides prevent the battery from fully charging.
- Storage: Keep your E350 stored indoors away from extreme temperature changes.
- Control Corrosion: Clean the terminals (toothbrush dipped in baking soda and water mixture) and keep them free from build-up.
How Long Do the Spark Plugs Last?
The spark plugs on a Mercedes-Benz E350 typically last around 60,000 miles.
Spark plugs are usually inspected, and if needed, replaced when you go for routine maintenance.
Signs of a fouled spark plug include:
- Reduced gas mileage
- Lack of acceleration
- Rough idling
- Hard starts
- Engine misfires
What About Insurance Cost?
The average cost for full comprehensive coverage for a Mercedes-Benz E350 is $1,834 per year or $153 per month. In comparison, its segment rivals cost an average of $2,005 per year to insure.
Insurance costs can vary from person to person; be sure to shop around to find the best possible deal for your E350.
Tips to Prolong the Life of Your Mercedes-Benz E350
- Adopt smooth driving habits.
- Keep your car clean, inside and out.
- Keep up to date with factory-recommended maintenance.
- Use quality parts and fluids.
- Don’t ignore gauges, lights or alerts.
- Keep on top of repairs to prevent them from developing into larger problems.
- Check your E350’s engine oil, coolant, brake, and transmission fluid levels and top them up when required.
- Keep your E350 in a garage or under a carport.
- Monitor filters.
- Read the owner’s manual to learn the location of important components, what your E350 needs and what quantity and to understand the symbols and dashboard warning lights.